Browsing by Author "Andreou, Chrysafis"

Now showing items 1-8 of 8

    • Article  

      Acid specific dark quencher QC1 pHLIP for multi-spectral optoacoustic diagnoses of breast cancer 

      Roberts, Sheryl; Strome, Arianna; Choi, Crystal; Andreou, Chrysafis; Kossatz, Susanne; Brand, Christian; Williams, Travis; Bradbury, Michelle; Kircher, Moritz F.; Reshetnyak, Yana K.; Grimm, Jan; Lewis, Jason S.; Reiner, Thomas (2019)
      Breast cancer is the most common type of malignant growth in women. Early detection of breast cancer, as well as the identification of possible metastatic spread poses a significant challenge because of the structural and ...
    • Article  

      Distorted Phthalocyanines by Click Chemistry: Photoacoustic, Photothermal, and Surface-Enhanced Resonance Raman Studies 

      Rizvi, Waqar; Berisha, Naxhije; Farley, Christopher; Bhupathiraju, N. V. S. Dinesh K.; Andreou, Chrysafis; Khwaja, Emaad; Fuentes, German V.; Kircher, Moritz F.; Gao, Ruomei; Drain, Charles Michael (2019)
      Abstract Distortion of nominally planar phthalocyanine macrocycles affects the excited state dynamics in that most of the excited-state energy decays through internal conversion. A click-type annulation reaction on a ...
    • Article  

      DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy 

      Pal, Suchetan; Ray, Angana; Andreou, Chrysafis; Zhou, Yadong; Rakshit, Tatini; Wlodarczyk, Marek; Maeda, Masatomo; Toledo-Crow, Ricardo; Berisha, Naxhije; Yang, Jiang; Hsu, Hsiao-Ting; Oseledchyk, Anton; Mondal, Jagannath; Zou, Shengli; Kircher, Moritz F. (2019)
      Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely ...
    • Article  

      Immunoengineering in glioblastoma imaging and therapy 

      Zanganeh, Steven; Georgala, Petrina; Corbo, Claudia; Arabi, Leila; Ho, Jim Q.; Javdani, Najme; Sepand, Mohammad R.; Cruickshank, Kiara; Campesato, Luis F.; Weng, Chien-Huan; Hemayat, Saeed; Andreou, Chrysafis; Alvim, Ricardo; Hutter, Gregor; Rafat, Marjan; Mahmoudi, Morteza (2019)
      Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on ...
    • Article  

      Non-invasive In Vivo Imaging of Cancer Using Surface-Enhanced Spatially Offset Raman Spectroscopy (SESORS) 

      Nicolson, Fay; Andreiuk, Bohdan; Andreou, Chrysafis; Hsu, Hsiao-Ting; Rudder, Scott; Kircher, Moritz F. (2019)
      Rationale: The goal of imaging tumors at depth with high sensitivity and specificity represents a significant challenge in the field of biomedical optical imaging. 'Surface enhanced Raman scattering' (SERS) nanoparticles ...
    • Article  

      Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors 

      Kaittanis, Charalambos; Andreou, Chrysafis; Hieronymus, Haley; Mao, Ninghui; Foss, Catherine A.; Eiber, Matthias; Weirich, Gregor; Panchal, Palak; Gopalan, Anuradha; Zurita, Juan; Achilefu, Samuel; Chiosis, Gabriela; Ponomarev, Vladimir; Schwaiger, Markus; Carver, Brett S.; Pomper, Martin G.; Grimm, Jan (2018)
      Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role ...
    • Article  

      Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer 

      Roberts, Sheryl; Andreou, Chrysafis; Choi, Crystal; Donabedian, Patrick; Jayaraman, Madhumitha; Pratt, Edwin C.; Tang, Jun; Pérez-Medina, Carlos; Cruz, M. Jason de la; Mulder, Willem J. M.; Grimm, Jan; Kircher, Moritz; Reiner, Thomas (2018)
      Optoacoustic imaging offers the promise of high spatial resolution and, at the same time, penetration depths well beyond the conventional optical imaging technologies, advantages that would be favorable for a variety of ...
    • Article  

      Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting 

      Andreou, Chrysafis; Oseledchyk, Anton; Nicolson, Fay; Berisha, Naxhije; Pal, Suchetan; Kircher, Moritz F. (2019)
      Ovarian cancer represents the deadliest gynecologic malignancy. Most patients present at an advanced stage (FIGO stage III or IV), when local metastatic spread has already occurred. However, ovarian cancer has a unique ...